Duodenal Cancer
Rare cancer of the duodenum requiring complex surgical management.
Overview
Primary duodenal cancer is rare, accounting for <1% of GI malignancies. Periampullary tumors (at the ampulla of Vater) present with jaundice and are treated with Whipple procedure. Non-ampullary duodenal cancers may allow segmental resection.
Causes
- Adenomatous polyps (duodenal adenoma)
- FAP (familial adenomatous polyposis)
- Celiac disease
- Crohn's disease
Risk Factors
- FAP
- Peutz-Jeghers syndrome
- Celiac disease
- Age over 60
Symptoms
Diagnosis
- Upper GI endoscopy with biopsy
- CT abdomen
- MRCP
- EUS
- Tumor markers (CEA, CA 19-9)
Treatment Options
Surgical Treatment
Periampullary adenocarcinoma: Whipple procedure (pancreaticoduodenectomy). Non-ampullary D3/D4 tumors: segmental resection if feasible. Endoscopic resection for early-stage duodenal adenomas. Dr. Bhagat trained extensively in Whipple procedures.
Recovery
Whipple: 7-10 days hospital stay. Segmental resection: 5-7 days. Adjuvant chemotherapy as indicated.
Prevention
- Surveillance endoscopy for FAP patients
- Remove duodenal adenomas when found
Frequently Asked Questions
Is duodenal cancer curable?
What is the ampulla of Vater?
Expert Consultation Available
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